Pittsburgh School of Medicine
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US scientists announce positive COVID-19 vaccine trials on mice; human trials to start soon .Governments around the world are looking frenziedly for a COVID-19 diagnosis. Now researchers at the School of Medicine at the University of Pittsburgh have confirmed a possible vaccine against SARS-CoV-2, the latest coronavirus that causes the COVID-19 pandemic after positive animal studies.
The vaccine, administered via a fingertip-sized patch, developed SARS-CoV-2-specific antibodies in amounts thought to be sufficient to neutralize the virus, the team said in a paper published by The Lancet on eBioMedicine.The authors are in the process of applying for a US Food and Drug Administration (FDA) investigational
new drug (IND) clearance in anticipation of a phase I human clinical trial starting in the coming months.
If positive after clinical trials, it will still take more than a year for the vaccine to enter the market. The team had previous experience in 2003on SARS-CoV and in 2014 on MERS-CoV. "These two viruses, which are closely related to SARS-CoV-2, tell us that a specific protein, called a spike protein, is essential for inducing immunity against the virus. We knew exactly where to fight this new virus," said co-senior author Andrea Gambotto, associate professor of surgery at the Pitt School of Medicine.
"This particular scenario is different from anything we've ever seen, and we don't know how long the phase of clinical development will take. Recently reported changes to the standard processes indicate we might be able to push much faster forward," the writers wrote. It is the first study that will be conducted after criticism
by fellow scientists at outside institutions that describes a COVID-19 candidate vaccine.
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